Experts in the Hot Seat: Targeting the Cytokine Pathway in RA Management

Title:

Experts in the Hot Seat: Targeting the Cytokine Pathway in RA Management

Topic: Rheumatology
Relevant Terms: Rheumatoid Arthritis, RA
Primary Audience: Physicians, nurse practitioners, and physician assistants who specialize in rheumatology and internal medicine
Launch Date: 28-Mar-17
Credits: 0.75 AMA PRA Category 1 Credit
Expiration Date: 28-Mar-18
Curriculum Name: Targeting the Cytokine Pathway in RA Management: Implications for Novel and Emerging IL-6...

Learning Objectives

After completing this activity, the participant will demonstrate the ability to:

  1. Delineate the role of TNF and IL-6 signaling pathways in the pathophysiology of rheumatoid arthritis and the rationale for anti-cytokine therapy as a treatment approach
  2. Integrate current standards for disease activity monitoring into informing appropriate management for patients with rheumatoid arthritis
  3. Incorporate emerging clinical trial data regarding the safety and efficacy of novel IL-6 targeting agents for RA into treatment decisions
  4. Select treatments for patients that improve patient outcomes based on an understanding of the differences between TNF cycling and switching

    Faculty

    Peter C. Taylor, MA, BM, BCh, PhD, FRCP, FRCPE
    Norman Collisson Professor of Musculoskeletal Sciences
    Oxford University
    Director of Clinical Sciences
    Botnar Research Centre
    Oxford, England
    Thomas Dörner, MD, PhD
    Professor of Rheumatology and Clinical Immunology
    Charite University Hospitals Berlin and DRFZ Berlin
    Berlin, Germany 
    Juan J. Gómez-Reino, MD, PhD
    Professor of Medicine
    Fundación Ramón Dominguez
    Hospital Clinico Universitario
    Santiago, Spain
    PHYSICIAN CONTINUING MEDICAL EDUCATION
    Accreditation Statement
    This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The Omnia-Prova Education Collaborative (TOPEC) and RMEI Medical Education, LLC. TOPEC is accredited by the ACCME to provide continuing medical education for physicians.
     
    Credit Designation
    The Omnia-Prova Education Collaborative, Inc. designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    DISCLOSURE OF CONFLICTS OF INTEREST
    In accordance with the ACCME Standards for Commercial Support, The Omnia-Prova Education Collaborative (TOPEC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. TOPEC resolves all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.
     
    The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:
    • Peter C. Taylor, MA, BM, BCh, PhD, FRCP, FRCPE, discloses the following relationships with commercial interests: AbbVie, Biogen, BMS, GSK, Janssen, Lilly, Novartis, Pfizer, Sandoz, Sanofi, and UCB (Consulting Fees); Abide Therapeutics, Celgene, Galapagos, GSK, and UCB (Contracted Research).
    • Thomas Dörner, MD, PhD, discloses the following relationships with commercial interests: Ablynx, Chugai, Eli Lilly, and Roche (Consulting Fees); Charite CRO, Janssen, and Sanofi (Contracted Research).
    • Juan J. Gómez-Reino, MD, PhD, discloses the following relationships with commercial interests: BMS, Pfizer (Consulting Fees); Roche (Contracted Research).
    RMEI Medical Education, LLC
    • Jacqui Brooks, MBBCh, MRCPsych, has no affiliations with commercial interests to disclose.
    • Beth Paczolt Weiner, MD, has no affiliations with commercial interests to disclose.
    • Nora Hartley has no affiliations with commercial interests to disclose.
    The Omnia-Prova Education Collaborative (TOPEC)
    • Sean T. Barrett has no affiliations with commercial interests to disclose.
    • Barry A. Fiedel, PhD, has no affiliations with commercial interests to disclose.
    DISCLAIMER
    Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients' conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.
     
    DISCLOSURE OF UNLABELED USE
    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of TOPEC and Omnia Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients' conditions and possible contraindications or dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of Omnia Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.
     
    Reproduction Prohibited
    Reproduction of this material is not permitted without written permission from the copyright owner.
      
    Estimated time to complete: 0.75 hours
    Medium: Internet

    FEE INFORMATION
    There is no fee for this educational activity.

    COMMERCIAL SUPPORT
    This activity is supported by an independent educational grant from Sanofi Genzyme and Regeneron Pharmaceuticals.  

    HOW TO RECEIVE CREDIT
    By reviewing the course content and successfully completing the post-test and evaluation, physicians, nurse practitioners, and physician assistants are entitled to receive up to 0.75 AMA PRA Category 1 Credit(s)™. A statement of credit will be available to print from your user history page. Users must:
    • Read the learning objectives and faculty disclosures.
    • Participate in the activity.
    • Complete the activity evaluation.
    Physicians, nurse practitioners, and physician assistants who successfully complete the post-test and evaluation will receive CME credit. You must score 75% or higher on the post-test to receive credit for this activity. All other participants who successfully complete the post-test and evaluation will receive a certificate of participation.

    COURSE VIEWING REQUIREMENTS
    Supported Browsers:
    Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
    Google Chrome 28.0+ for Windows, Mac OS, or Linux
    Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
    Safari 6.0+ for Mac OSX 10.7 and above

     
    Supported Phones & Tablets:
    Android 4.0.3 and above
    iPhone/iPad with iOS 6.1 or above.